Protein damage susceptibility (6 Å)

Protein damage susceptibility (7 Å)

Enzymes Organisms

Fichtner M, Schuster S & Stark H (2020) Determination of scoring functions for protein damage susceptibility. Biosystems 187: 104035.
DOI:10.1016/J.BIOSYSTEMS.2019.104035

Fichtner M, Schuster S & Stark H (2020) Influence of spatial structure on protein damage susceptibility – A bioinformatics approach.
BioRxiv:2020.03.03.973099; DOI:10.1101/2020.03.03.973099

Low values = less susceptible / High values = more susceptible Black line = randomly assembled protein (value = 5)


Distribution of all peptides/proteins	Distribution of selected peptides/proteins	Distribution of hidden values
(red)	(blue)	(shortened blue bars)

Neuro
	All	Core	Surface	Only sidechain (-backbone)	Only backbone (-sidechain)
Amyloid
Tau
Prion
Transthyretin

Connective tissue
	All	Core	Surface	Only sidechain (-backbone)	Only backbone (-sidechain)
Collagen
Keratin

Toplist (lower)
	All	Core	Surface	Only sidechain (-backbone)	Only backbone (-sidechain)
Capsid
Flagellin
Spidroin
Antifreeze
Heat shock
Fucose-binding lectin

Toplist (higher)
	All	Core	Surface	Only sidechain (-backbone)	Only backbone (-sidechain)
Toxi
Phospholipase
Phosphatase
Calmodulin

Add-On
	All	Core	Surface	Only sidechain (-backbone)	Only backbone (-sidechain)
Polymerase
DNA
RNA
Ribosomal
NADH
Cytochrome A
Cytochrome B
Cytochrome C
Mitochondral